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Symptom

High white blood cell count

Learn the causes of this increase in disease-fighting cells in the blood.

  • Definition
  • Causes
  • When to see a doctor

Definition

A high white blood cell count is a rise in the number of cells in the blood that fight infections.

What's thought of as high in a white blood cell count varies from one lab to another. This is because labs set their own reference ranges based on the people they serve. Most often, a count of more than 11,000 white blood cells in a microliter of blood is thought to be high for adults.

Causes

A high white blood cell count most often means one of the following has led to a rise in white blood cells:

  • An infection.
  • Reaction to a medicine.
  • A bone marrow condition.
  • An immune system issue.
  • Sudden stress such as hard exercise.
  • Smoking.

Specific causes of a high white blood cell count include:

  • Allergy, mainly bad allergic reactions
  • Asthma
  • Bacterial, viral, fungal or parasitic infections
  • Burns
  • EGPA (formerly Churg-Strauss syndrome)
  • Medicines, such as corticosteroids and epinephrine
  • Hay fever
  • Leukemia
  • Lymphoma
  • Myelofibrosis
  • Polycythemia vera
  • Pregnancy
  • Rheumatoid arthritis
  • Sarcoidosis
  • Smoking
  • Tuberculosis
  • Vasculitis
  • Whooping cough

When to see a doctor

A test a healthcare professional orders to diagnose a condition can show a high white blood cell count. A high white blood cell count rarely is found by chance.

Talk to your healthcare professional about what your results mean. A high white blood cell count plus results from other tests might show the cause of your illness. Or you might need other tests for more information about your condition.

© 1998-2026 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved.
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