Please make sure the following documents are provided along with the sample:
- Request form
- Consent Form
- Medical history
- Additional patient medical reports
Our testing services deliver important insights on clinically related variations in DNA that cause cancer. This aids healthcare professionals in preparing early management and treatment plans for their patients.
Gene variations that cause cancer can occur due to environment or lifestyle factors (e.g. smoking or ultraviolet light exposure). They can also occur arbitrarily as we age and/or can also be inherited. Hereditary cancer occurs when an individual inherits a gene variation from one of their parents, which increases the likelihood and the risk for certain types of cancer. Each cancer is unique and each tumour can vary at the molecular level.
Precise Comp Cancer
Our test is a next generation sequencing (NGS)-based assay that detects genomic variations significant for the diagnosis and treatment of solid tumours which is in line with up to date clinical guidelines and medical literature. Our test includes screening of over 500 cancer-related genes, cancer immunotherapy biomarkers and forms of genomic alterations.
Precise Target Cancer
Our test is a next generation sequencing (NGS)-based assay that detects specific variants within genes known to be associated with cancers. Assessing multiple gene targets of solid tumours will help determine prognosis for patients with solid tumours. This test evaluates somatic variants within multiple genes associated with cancer.
Precise Hereditary Cancer
Genetic testing for hereditary cancer looks for gene variations in what are called germline cells, which are passed from parent to child. Germline DNA variations in certain genes linked with cancer risk are inherited variations and cause increased cancer risk to different generations in a family.
Our test is a next generation sequencing (NGS)-based assay…
Our testing services provide results that can be harnessed as a tool to help clarify a patient’s risk for cardiovascular conditions. In turn this will help healthcare professionals to determine the best plan of action for their patient moving forward.
Heart diseases are common, and they can occur for multiple reasons. Most cardiac (heart) diseases are due to risk factors in health (such as diabetes, cholesterol and blood pressure) lifestyle, diet, race, biological sex or certain medications. Cardiac diseases can also be due to plaque buildup in the arteries (atherosclerosis), strokes and most heart attacks. However, cardiac disease can also be inherited. Genetic cardiac disease is due to changes in genes, which we inherit from either parent and can pass to our children. Inherited heart conditions can run in families and can occur to people of all ages and backgrounds.
Our test is a next generation sequencing (NGS)-based assay that detects specific variants within genes known to be associated with heart diseases. It is a targeted panel for patients with inherited cardiomyopathies and arrhythmias, and other inherited cardiovascular conditions. Given the clinical and genetic commonality between these disorders, a single comprehensive inherited cardiovascular test may be the most effective way of identifying individuals who are at risk, or confirming a diagnosis.
You and your partner may be interested in the health of your developing baby during pregnancy. There are options such as prenatal screening tests that pose no risk to your pregnancy. There are many options for screening of chromosome abnormalities during a pregnancy.
Currently, Mediclinic Precise offers cell-free DNA testing with genetic counselling services to help you understand your risks for genetic conditions or birth defects in pregnancy.
Cell-free DNA Testing
Cell-free DNA (cfDNA) testing and/or Non-invasive prenatal testing (NIPT) is a genetic test that can be taken as early as 10 weeks into your pregnancy to screen for specific chromosomal abnormalities that might affect the health of your baby. NIPT are also sometimes used to determine the gender of your baby at an earlier stage than ultrasound. Mediclinic Precise NIPT test screens for all the common trisomies and sex chromosomes. With that in mind the guidelines from the American College of Obstetrics and Gynecologists (ACOG) recommend Non-Invasive Prenatal Testing (NIPT) to be made available to all pregnant women, regardless of maternal age or baseline risk.
When a patient’s clinical and/or family history strongly suggest an underlying genetic cause for their signs and symptoms, it is recommended to perform whole exome sequencing.
Whole exome sequencing (WES) is available to patients who are searching for a unifying diagnosis for several medical issues.
Unlike older technology where only a single gene could be tested at a time, Mediclinic Precise uses state-of-the-art technology to examine an individual’s exome. WES is a genomic technique for sequencing of all protein-coding regions of genes (exons) in a genome. In WES, more than 20,000 protein-coding regions of all genes (exons) are sequenced, employing high throughput next-generation sequencing technologies. WES targets all protein-coding regions which only constitute to ~1% of the whole genome, however, this region is responsible for 85% of known disease-causing variants. This is the reason exome sequencing is seen as a cost-effective alternative to whole genome sequencing. WES is a robust and comprehensive genetic test that improves molecular diagnosis of genetic diseases by enabling the exploration of novel variants. Compared to whole genome sequencing, WES has the advantage of a greater sequencing depth and delivers more effective data. Whether you need to detect variants in rare diseases, cancers, heart diseases, and complex disorders, Mediclinic Precise’s comprehensive whole exome sequencing (WES) service provides a high-quality, affordable, and convenient solution.
For patients with symptoms of genetic disorders, Mediclinic Precise’s whole exome sequencing plays a significant role in rapidly detecting possible variants. It offers a one-step solution for individuals with complex phenotypes with multiple differential diagnoses, inconclusive previous genetic tests, patients with genetic heterogeneity and where it is unclear which genes cause specific genetic conditions. Mediclinic Precise’s WES process is validated and performed in a CAP-accredited laboratory to achieve and ensure high standards in quality, accuracy and performance, with the whole process being under strict quality control, and providing precise diagnosis.
For doctors submitting samples for WES, test details should include:
- Test name
- Test code
- Genes being tested
- CPT codes
- Specimen types
- Reasons for rejections
- Turn around time
Genetic counsellors have advanced training in medical genetics and counseling to interpret genetic test results and to guide and support patients seeking more information about things such as:
- How inherited diseases and conditions might affect them or their families
- How family and medical histories may impact the chance of disease occurrence or recurrence
- Which genetic tests may or may not be right for them, and what those tests may or may not say
- How to make the most informed choices about healthcare conditions
Our clinical geneticists and genetic counsellors provide patients with a continuum of care throughout their diagnosis, genetic testing and post-test journey.
Above all, we emphasise close communication between our various team members, our patients and their family, to empower them with information regarding their healthcare and facilitate informed decision making.